Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors. Kutay Karatepe, Bruna Mafra de Faria, Jian zhang, Xinyue Chen, Hugo Pinto, Dmitry Fyodorov, Esen Sefik, Michael Willcockson, Richard Flavell, Arthur I Skoultchi, Shangqin Guo. https://www.biorxiv.org/content/10.1101/2024.09.16.613227v2
Finetuning ERK activity enables most somatic cells to reprogram into pluripotency. Qiao Wu, Jian Zhang, Xiao Hu, Bruna Mafra de Faria, Steven Maxwell Scalf, Kutay Karatepe, Ananda L Roy, Shangqin Guo. https://www.biorxiv.org/content/10.1101/2023.06.02.543427v1
Serum response factor reduces gene expression noise and confers cell state stability. Jian Zhang, Xiao Hu, Qiao Wu and Shangqin Guo. Stem Cells. Oct 8, 2023.
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling. Xing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Müschen, Jungmin Choi , Joao Pedro Pereira. eLife. Mar 13, 2023
Incorporating signaling dynamics into fate decision. Shangqin Guo. Blood. Jul 14;140(2):79-80, 2022.
Integrating mechanical signals into cellular identity. Emma Carley, Megan C. King and Shangqin Guo. Trends in Cell Biology, March 23, 2022.
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, Yung Hwang, S Maxwell Scalf, Anna E Eastman, Jane-Jane Chen, Lihua Julie Zhu, Jules A A C Heuberger, Shangqin Guo, Mark J Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky. Nat Commun. 2021 Dec 17;12(1):7334.
Reprogramming progressive cells display low CAG promoter activity. Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman A, Eastman AE, Park I, Guo S. Stem Cells, 2021 Jan;39(1):43-54.
Resolving cell cycle speed in one snapshot with a live-cell fluorescent reporter. Eastman AE, Chen X, Hu X, Hartman A, Morales A, Yang C, Lu J, Kueh HY, Guo S. Cell Reports, Jun 23, 2020.
The palette of techniques for cell cycle analysis. Eastman AE, Guo S. FEBS Letter, May. 22, 2020.
Non-cell-autonomous promotion of pluripotency induction mediated by YAP. Hartman A, Scalf SM, Zhang J, Hu X, Chen X, Eastman AE, Yang C, Guo S. Stem Cell Reports, Mar 24, 2020
Collisions on the busy DNA highway set up barriers for reprogramming. Hu X,Guo S. Cell Stem Cell, Oct 03, 2019
Cell cycle dynamics in the reprogramming of cellular identity. Hu X, Eastman AE, Guo S. FEBS Letter, Sep. 28, 2019
MLL-AF9 Initiates Transformation From Fast-Proliferating Myeloid Progenitors. Chen X, Burkhardt D, Hartman A, Wang X, Hu X, Eastman AE, Zhong Mei, Krishnaswamyand S, Guo S. Nat Commun. 2019. Dec18
Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Hetzler PT, Dash BC, Guo S and Hsia HC. Annals of Plastic Surgery, Jun 25, 2019.
MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J Schwartz M, King MC, Krause DS, Guo S. Nat Commun. 2019 Apr 12;10(1):1695.
Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Hernandez C, Wang Z, Ramazanov B, Tang Y, Mehta S, Dambrot C, Lee YW, Tessema K, Kumar I, Astudillo M, Neubert TA, Guo S, Ivanova NB. Cell Stem Cell. 2018 Sep 6;23(3):396-411
miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Liu J, Guo B, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pan W, Khan S, Chen S, Kyba M, Fan R, Guo S, Lu J. Blood. 2017 Mar 16;129(11):1491-1502
A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J. Nat Commun. 2016 Mar 30;7:11178
Choosing Cell Fate Through a Dynamic Cell Cycle. Chen X, Hartman A and Guo S, Current Stem Cell Reports September 2015, Volume 1, Issue 3, pp 129-138
Non-stochastic reprogramming from a privileged somatic cell state. Guo S (corresponding author), Zi X, Schulz, VP, Cheng J, Zhong M, Koochaki SHJ, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan Rand Lu J. Cell, Feb 13, 2014
An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis. Cheng J, Guo S (co-first and co-corresponding author), Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J. Cell Rep. 2013 Oct 31;5(2):471-81.
Piwi Genes are Dispensable for Normal Hematopoiesis in Mice. Noodle MJ, Cheng E, Guo S and Lin H. PlosOne, 2013 Aug 23;8(8):e71950.
Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng EC, Nottoli T, Krause DS, Lu J, Guo S. Stem Cells. 2013 May;31(5):895-905.
An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response. Adams BD, Guo S, Bai H, Cheng J, Xiao C, Reddy EP, and Lu J. Cell Report, 2012 Oct 17
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Proc Natl Acad Sci. 2012 Oct 9;109(41):16636-41.
A microRNA regulating adult hematopoietic stem cells. Guo S, Scadden DT. Cell Cycle. 2010 Sep 15;9(18):3637-8.
MicroRNA miR-125a controls hematopoietic stem cell number. Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. Proc Natl Acad Sci. 2010 Aug 10;107(32):14229-34.
Compartmentalized organization: a common and required feature of stem cell niches? Greco V, Guo S. Development. 2010 May;137(10):1586-94.